Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral <i>Sarcophyton elegans</i>

Cili Wang; Jiarui Zhang; Xing Shi; Kai Li; Fengling Li; Xuli Tang; Guoqiang Li; Pinglin Li

doi:10.3390/md20090574

Marine Drugs (Sep 2022)

Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral <i>Sarcophyton elegans</i>

Cili Wang,
Jiarui Zhang,
Xing Shi,
Kai Li,
Fengling Li,
Xuli Tang,
Guoqiang Li,
Pinglin Li

Affiliations

Cili Wang: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Jiarui Zhang: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Xing Shi: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Kai Li: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Fengling Li: Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China
Xuli Tang: College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China
Guoqiang Li: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Pinglin Li: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

DOI: https://doi.org/10.3390/md20090574
Journal volume & issue: Vol. 20, no. 9
p. 574

Abstract

Read online

Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

About the journal

Abstract

Keywords