Nature Communications (Nov 2021)
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
- Tingting Li,
- Xiaojian Han,
- Chenjian Gu,
- Hangtian Guo,
- Huajun Zhang,
- Yingming Wang,
- Chao Hu,
- Kai Wang,
- Fengjiang Liu,
- Feiyang Luo,
- Yanan Zhang,
- Jie Hu,
- Wang Wang,
- Shenglong Li,
- Yanan Hao,
- Meiying Shen,
- Jingjing Huang,
- Yingyi Long,
- Shuyi Song,
- Ruixin Wu,
- Song Mu,
- Qian Chen,
- Fengxia Gao,
- Jianwei Wang,
- Shunhua Long,
- Luo Li,
- Yang Wu,
- Yan Gao,
- Wei Xu,
- Xia Cai,
- Di Qu,
- Zherui Zhang,
- Hongqing Zhang,
- Na Li,
- Qingzhu Gao,
- Guiji Zhang,
- Changlong He,
- Wei Wang,
- Xiaoyun Ji,
- Ni Tang,
- Zhenghong Yuan,
- Youhua Xie,
- Haitao Yang,
- Bo Zhang,
- Ailong Huang,
- Aishun Jin
Affiliations
- Tingting Li
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Xiaojian Han
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Chenjian Gu
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Hangtian Guo
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Huajun Zhang
- State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Yingming Wang
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Chao Hu
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Kai Wang
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Fengjiang Liu
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Feiyang Luo
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Yanan Zhang
- Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Jie Hu
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Wang Wang
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Shenglong Li
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Yanan Hao
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Meiying Shen
- Department of Breast Surgery, Harbin Medical University Cancer Hospital
- Jingjing Huang
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Yingyi Long
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Shuyi Song
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Ruixin Wu
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Song Mu
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Qian Chen
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Fengxia Gao
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Jianwei Wang
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Shunhua Long
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Luo Li
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- Yang Wu
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Yan Gao
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Wei Xu
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Xia Cai
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Di Qu
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Zherui Zhang
- Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Hongqing Zhang
- Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Na Li
- Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Qingzhu Gao
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Guiji Zhang
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Changlong He
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Wei Wang
- Institute of life sciences, Chongqing Medical University
- Xiaoyun Ji
- State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Ni Tang
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Zhenghong Yuan
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Youhua Xie
- Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
- Haitao Yang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Bo Zhang
- Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
- Ailong Huang
- Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University
- Aishun Jin
- Department of Immunology, College of Basic Medicine, Chongqing Medical University
- DOI
- https://doi.org/10.1038/s41467-021-26539-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.
