Nature Communications (Jan 2019)
Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
- Shaopeng Zhang,
- Tianzhi Chen,
- Naixin Chen,
- Dengfeng Gao,
- Bingbo Shi,
- Shuangbo Kong,
- Rachel Claire West,
- Ye Yuan,
- Minglei Zhi,
- Qingqing Wei,
- Jinzhu Xiang,
- Haiyuan Mu,
- Liang Yue,
- Xiaohua Lei,
- Xuepeng Wang,
- Liang Zhong,
- Hui Liang,
- Suying Cao,
- Juan Carlos Izpisua Belmonte,
- Haibin Wang,
- Jianyong Han
Affiliations
- Shaopeng Zhang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Tianzhi Chen
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Naixin Chen
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Dengfeng Gao
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Bingbo Shi
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Shuangbo Kong
- Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University
- Rachel Claire West
- Colorado Center for Reproductive Medicine
- Ye Yuan
- Colorado Center for Reproductive Medicine
- Minglei Zhi
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Qingqing Wei
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Jinzhu Xiang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Haiyuan Mu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Liang Yue
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Xiaohua Lei
- State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
- Xuepeng Wang
- State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
- Liang Zhong
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Hui Liang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Suying Cao
- Animal Science and Technology College, Beijing University of Agriculture
- Juan Carlos Izpisua Belmonte
- Salk Institute for Biological Studies
- Haibin Wang
- Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University
- Jianyong Han
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-019-08378-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implantation response.
