Nature Communications (Mar 2023)
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases
- Beatriz Trastoy,
- Jonathan J. Du,
- Javier O. Cifuente,
- Lorena Rudolph,
- Mikel García-Alija,
- Erik H. Klontz,
- Daniel Deredge,
- Nazneen Sultana,
- Chau G. Huynh,
- Maria W. Flowers,
- Chao Li,
- Diego E. Sastre,
- Lai-Xi Wang,
- Francisco Corzana,
- Alvaro Mallagaray,
- Eric J. Sundberg,
- Marcelo E. Guerin
Affiliations
- Beatriz Trastoy
- Structural Glycobiology Laboratory, Biocruces Health Research Institute
- Jonathan J. Du
- Department of Biochemistry, Emory University School of Medicine
- Javier O. Cifuente
- Structural Glycobiology Laboratory, Biocruces Health Research Institute
- Lorena Rudolph
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Mikel García-Alija
- Structural Glycobiology Laboratory, Biocruces Health Research Institute
- Erik H. Klontz
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Daniel Deredge
- Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy
- Nazneen Sultana
- Department of Biochemistry, Emory University School of Medicine
- Chau G. Huynh
- Department of Biochemistry, Emory University School of Medicine
- Maria W. Flowers
- Department of Biochemistry, Emory University School of Medicine
- Chao Li
- Department of Chemistry and Biochemistry, University of Maryland
- Diego E. Sastre
- Department of Biochemistry, Emory University School of Medicine
- Lai-Xi Wang
- Department of Chemistry and Biochemistry, University of Maryland
- Francisco Corzana
- Departamento Química and Centro de Investigación en Síntesis Quı́mica, Universidad de La Rioja
- Alvaro Mallagaray
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Eric J. Sundberg
- Department of Biochemistry, Emory University School of Medicine
- Marcelo E. Guerin
- Structural Glycobiology Laboratory, Biocruces Health Research Institute
- DOI
- https://doi.org/10.1038/s41467-023-37215-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by the multi-modular enzymes EndoS and EndoS2
