Frontiers in Endocrinology (Oct 2020)

Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Obesity

  • Marta Borges-Canha,
  • Marta Borges-Canha,
  • João Sérgio Neves,
  • João Sérgio Neves,
  • Fernando Mendonça,
  • Maria Manuel Silva,
  • Cláudia Costa,
  • Pedro M. Cabral,
  • Vanessa Guerreiro,
  • Rita Lourenço,
  • Patrícia Meira,
  • Daniela Salazar,
  • Maria João Ferreira,
  • Jorge Pedro,
  • Ana Leite,
  • Madalena Von-Hafe,
  • Catarina Vale,
  • Sara Viana,
  • Ana Sande,
  • Sandra Belo,
  • Eva Lau,
  • Paula Freitas,
  • Paula Freitas,
  • Davide Carvalho,
  • Davide Carvalho

DOI
https://doi.org/10.3389/fendo.2020.572128
Journal volume & issue
Vol. 11

Abstract

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BackgroundAn association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity.AimTo evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity.MethodsPatients with morbid obesity followed in our center between January 2010 and July 2018 were included. The ones without evaluation of liver and thyroid functions were excluded. Fatty Liver Index (FLI) and BARD scores were used as predictors of hepatic steatosis and fibrosis, respectively.ResultsWe observed a positive association between TSH and both BARD (OR 1.14; p = 0.035) and FLI (OR 1.19; p = 0.010) in the unadjusted analysis. We found a negative association between free triiodothyronine levels and BARD (OR 0.70; p<0.01) and a positive association between free triiodothyronine levels and FLI (OR 1.48; p = 0.022). Concerning liver function, we found a positive association between total bilirubin and free thyroxine levels (β = 0.18 [0.02 to 0.35]; p = 0.033) and a negative association between total bilirubin and free triiodothyronine levels (β = −0.07 [−0.14 to −0.002]; p = 0.042).ConclusionHigher levels of TSH and free triiodothyronine may be associated with a higher risk of NAFLD, particularly steatosis, in patients with morbid obesity.

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