Evaluating a therapeutic window for precision medicine by integrating genomic profiles and p53 network dynamics

Minsoo Choi; Sang-Min Park; Kwang-Hyun Cho

doi:10.1038/s42003-022-03872-1

Communications Biology (Sep 2022)

Evaluating a therapeutic window for precision medicine by integrating genomic profiles and p53 network dynamics

Minsoo Choi,
Sang-Min Park,
Kwang-Hyun Cho

Affiliations

Minsoo Choi: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Sang-Min Park: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Kwang-Hyun Cho: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s42003-022-03872-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

A network dynamics-based approach is used to screen for the therapeutic windows of drug combinations and explore the response of the p53 network to drugs in different patients and cell lines.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal