Nature Communications (Feb 2023)
GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Abstract
Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce pathology associated with atherosclerotic disease.