Frontiers in Immunology (Mar 2022)
Neuroinflammation Following Traumatic Brain Injury: Take It Seriously or Not
- Rui-zhe Zheng,
- Rui-zhe Zheng,
- Rui-zhe Zheng,
- Rui-zhe Zheng,
- Rui-zhe Zheng,
- Rui-zhe Zheng,
- Kuin-yu Lee,
- Zeng-xin Qi,
- Zeng-xin Qi,
- Zeng-xin Qi,
- Zeng-xin Qi,
- Zeng-xin Qi,
- Zeng-xin Qi,
- Zhe Wang,
- Zhe Wang,
- Zhe Wang,
- Zhe Wang,
- Zhe Wang,
- Zhe Wang,
- Ze-yu Xu,
- Ze-yu Xu,
- Ze-yu Xu,
- Ze-yu Xu,
- Ze-yu Xu,
- Ze-yu Xu,
- Xue-hai Wu,
- Xue-hai Wu,
- Xue-hai Wu,
- Xue-hai Wu,
- Xue-hai Wu,
- Xue-hai Wu,
- Ying Mao,
- Ying Mao,
- Ying Mao,
- Ying Mao,
- Ying Mao,
- Ying Mao
Affiliations
- Rui-zhe Zheng
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Rui-zhe Zheng
- National Center for Neurological Disorders, Shanghai, China
- Rui-zhe Zheng
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Rui-zhe Zheng
- Neurosurgical Institute of Fudan University, Shanghai, China
- Rui-zhe Zheng
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Rui-zhe Zheng
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- Kuin-yu Lee
- Department of Integrative Medicine and Neurobiology, Institute of Integrative Medicine of Fudan University Institute of Brain Science, School of Basic Medical Sciences, Fudan University, Shanghai, China
- Zeng-xin Qi
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Zeng-xin Qi
- National Center for Neurological Disorders, Shanghai, China
- Zeng-xin Qi
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Zeng-xin Qi
- Neurosurgical Institute of Fudan University, Shanghai, China
- Zeng-xin Qi
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Zeng-xin Qi
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- Zhe Wang
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Zhe Wang
- National Center for Neurological Disorders, Shanghai, China
- Zhe Wang
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Zhe Wang
- Neurosurgical Institute of Fudan University, Shanghai, China
- Zhe Wang
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Zhe Wang
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- Ze-yu Xu
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Ze-yu Xu
- National Center for Neurological Disorders, Shanghai, China
- Ze-yu Xu
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Ze-yu Xu
- Neurosurgical Institute of Fudan University, Shanghai, China
- Ze-yu Xu
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Ze-yu Xu
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- Xue-hai Wu
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Xue-hai Wu
- National Center for Neurological Disorders, Shanghai, China
- Xue-hai Wu
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Xue-hai Wu
- Neurosurgical Institute of Fudan University, Shanghai, China
- Xue-hai Wu
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Xue-hai Wu
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- Ying Mao
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Ying Mao
- National Center for Neurological Disorders, Shanghai, China
- Ying Mao
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Ying Mao
- Neurosurgical Institute of Fudan University, Shanghai, China
- Ying Mao
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Ying Mao
- State Key Laboratory of Medical Neurobiology and Ministry of Education (MOE) Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
- DOI
- https://doi.org/10.3389/fimmu.2022.855701
- Journal volume & issue
-
Vol. 13
Abstract
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial socioeconomic burden. With the standardization of the treatment process, there is increasing interest in the role that the secondary insult of TBI plays in outcome heterogeneity. The secondary insult is neither detrimental nor beneficial in an absolute sense, among which the inflammatory response was a complex cascade of events and can thus be regarded as a double-edged sword. Therefore, clinicians should take the generation and balance of neuroinflammation following TBI seriously. In this review, we summarize the current human and animal model studies of neuroinflammation and provide a better understanding of the inflammatory response in the different stages of TBI. In particular, advances in neuroinflammation using proteomic and transcriptomic techniques have enabled us to identify a functional specific delineation of the immune cell in TBI patients. Based on recent advances in our understanding of immune cell activation, we present the difference between diffuse axonal injury and focal brain injury. In addition, we give a figurative profiling of the general paradigm in the pre- and post-injury inflammatory settings employing a bow-tie framework.
Keywords
