Clinical Interventions in Aging (Jul 2021)
Osteoporosis and Endplate Damage Correlation Using a Combined Approach of Hounsfield Unit Values and Total Endplate Scores: A Retrospective Cross-Sectional Study
Abstract
Chenyang Zhuang,1,* Zixiang Wang,1,* Weisin Chen,1 Bo Tian,1 Juan Li,1,2 Hong Lin1,2 1Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Orthopedics, Shanghai Geriatrics Center, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan LiDepartment of Orthopedics, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, People’s Republic of ChinaTel/Fax +86 21 6404 1990Email [email protected] LinDepartment of Orthopedics, Shanghai Geriatrics Center, Fudan University, No. 2560 Chunshen Road, Shanghai, 201104, People’s Republic of ChinaEmail [email protected]: Osteoporosis and endplate damage, two primary orthopedic disorders that have adverse effects on the quality of life of older adults, may have some previously unknown relationship. The purpose of this study was to determine the potential association between osteoporosis and endplate damage with two specific imaging scoring systems and analyze the underlying mechanisms.Patients and Methods: A cross-sectional study including 156 patients with degenerative disc disease (DDD) who visited our department in 2018 was performed. Data including age, sex, body mass index, Hounsfield unit (HU) values utilizing computed tomography (CT), and total endplate scores (TEPSs) using magnetic resonance imaging (MRI) of all patients were retrospectively collected and analyzed. The average HU value and TEPS of L1–L4 were used to represent the degrees of bone mineral density (BMD) and endplate damage, respectively. Patients with an HU value < 110 were defined as having osteoporosis and placed in the low-BMD group; otherwise, they were placed in the normal-BMD group. Multivariate logistic regression models were used to determine the independent factors of endplate damage.Results: The TEPSs in the low-BMD group were significantly higher (6.4 ± 1.6 vs 5.0 ± 0.9, p < 0.001) overall and in every segment of L1–L4 (p < 0.01). A significant negative correlation was found between TEPS and HU values (p < 0.001). The HU value (odds ratio [OR] 0.221; 95% confidence interval [CI], 0.148– 0.295, p < 0.001), age (OR 0.047; 95% CI, 0.029– 0.224, p < 0.001), and BMD (OR 3.796; 95% CI, 2.11– 7.382, p < 0.05) were independent factors influencing endplate damage.Conclusion: A significantly positive correlation was observed between osteoporosis and endplate damage, indicating the requirement for a more comprehensive therapeutic regimen for treating patients with DDD complicated with osteoporosis.Keywords: degenerative disc diseases, bone mineral density, computed tomography, magnetic resonance imaging
