Біологічні студії (Sep 2009)

Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells

  • L. S. Starykovych,
  • M. O. Starykovych,
  • A. N. Rechytskyi,
  • V. A. Yeresko,
  • T. U. Kosyak,
  • N. O. Sybirna

DOI
https://doi.org/10.30970/sbi.0302.028
Journal volume & issue
Vol. 3, no. 2
pp. 93 – 98

Abstract

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Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, res­pectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompa­nied by apoptotic fragmen­tation of nuclear DNA.

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