Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Mami Ishikuro; Taku Obara; Keiko Murakami; Fumihiko Ueno; Aoi Noda; Tomomi Onuma; Fumiko Matsuzaki; Masahiro Kikuya; Zen Watanabe; Naomi Shiga; Masahito Tachibana; Noriyuki Iwama; Hirotaka Hamada; Masatoshi Saito; Junichi Sugawara; Hirohito Metoki; Nobuo Yaegashi; Shinichi Kuriyama

doi:10.3390/reprodmed4020010

Reproductive Medicine (Apr 2023)

Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Mami Ishikuro,
Taku Obara,
Keiko Murakami,
Fumihiko Ueno,
Aoi Noda,
Tomomi Onuma,
Fumiko Matsuzaki,
Masahiro Kikuya,
Zen Watanabe,
Naomi Shiga,
Masahito Tachibana,
Noriyuki Iwama,
Hirotaka Hamada,
Masatoshi Saito,
Junichi Sugawara,
Hirohito Metoki,
Nobuo Yaegashi,
Shinichi Kuriyama

Affiliations

Mami Ishikuro: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Taku Obara: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Keiko Murakami: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Fumihiko Ueno: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Aoi Noda: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Tomomi Onuma: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Fumiko Matsuzaki: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Masahiro Kikuya: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Zen Watanabe: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Naomi Shiga: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Masahito Tachibana: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Noriyuki Iwama: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Hirotaka Hamada: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Masatoshi Saito: Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Junichi Sugawara: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Hirohito Metoki: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Nobuo Yaegashi: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Shinichi Kuriyama: Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan

DOI: https://doi.org/10.3390/reprodmed4020010
Journal volume & issue: Vol. 4, no. 2
pp. 89 – 99

Abstract

Read online

Infertility treatment is a possible factor in hypertensive disorders of pregnancy (HDP). Identifying the characteristics of pregnant women who have undergone infertility treatment and have a potential risk for HDP is valuable for its prevention and treatment. Using data from 12,456 pregnant Japanese women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, the association between infertility treatment and HDP was analyzed. A multiple logistic regression model showed an association between infertility treatment and HDP (odds ratio, 1.34; 95% confidence interval, 1.05–1.72). In vitro fertilization/intracytoplasmic sperm injection were also associated with HDP. Moreover, these associations were observed even among women who were not overweight and did not smoke. The application of infertility treatment should be carefully considered, even among women with low modifiable risk factors.

Published in Reproductive Medicine

ISSN: 2673-3897 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Reproduction
Website: https://www.mdpi.com/journal/reprodmed

About the journal

Abstract

Keywords