Brainstem glioma: Clinical significance and prognostic evaluation

Ravindra Pramod Deshpande; Y.B.V.K. Chandrasekhar; Deepak Babu; I. Satish Rao; Manas Panigrahi; Phanithi Prakash Babu

Interdisciplinary Neurosurgery (Jun 2019)

Brainstem glioma: Clinical significance and prognostic evaluation

Ravindra Pramod Deshpande,
Y.B.V.K. Chandrasekhar,
Deepak Babu,
I. Satish Rao,
Manas Panigrahi,
Phanithi Prakash Babu

Affiliations

Ravindra Pramod Deshpande: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India
Y.B.V.K. Chandrasekhar: Department of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, India
Deepak Babu: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India
I. Satish Rao: Department of Pathology, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, India
Manas Panigrahi: Department of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana State, India
Phanithi Prakash Babu: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India; Corresponding author at: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana State, India.

Journal volume & issue: Vol. 16
pp. 64 – 66

Abstract

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In the present study, we have determined the prognostic value and observed the clinicopathological features of brainstem glioma. Overall, we found more number of male patients with brainstem glioma (male:female ratio: 1:6). All patients were subjected to surgery followed by chemotherapy. The tumor was mainly located at brainstem and thalamus. We have recorded the symptoms associated with onset of lesions and predominated by headache, vomiting and limb weakness. We observed the overall survival pattern in brain stem glioma cases and further among low and high grade subgroups. Patients with high grade brainstem glioma were recorded with the median survival of 15 months. There was a statistically significant difference in the survival pattern of low grade vs high grade group (p = 0.015, hazard ratio: 0.29, 95% CI of ratio: 0.058 to 0.71) Taken together, the clinical presentation provides valuable information to enhance the therapeutic measures for the brainstem glioma cases. Keywords: Brainstem, Glioma, Surgery

Published in Interdisciplinary Neurosurgery

ISSN: 2214-7519 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Surgery; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/interdisciplinary-neurosurgery/

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