Frontiers in Pediatrics (Nov 2021)

Prognostic Value of Biomarkers in Children and Adolescents With Orthostatic Intolerance

  • Huijuan Yan,
  • Shuo Wang,
  • Hong Cai,
  • Juan Zhang,
  • Ping Liu,
  • Yuwen Wang,
  • Runmei Zou,
  • Cheng Wang

DOI
https://doi.org/10.3389/fped.2021.752123
Journal volume & issue
Vol. 9

Abstract

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Orthostatic intolerance (OI) refers to a series of symptoms that occur during upright standing, which can be relieved when returned to the supine position. OI is a common cause of syncope in children and adolescents. In recent years, more and more studies have been carried out to assess the prognosis of OI by using biomarkers, among which, flow-mediated vasodilation, left ventricular ejection fraction and fractional shortening, hemodynamic change during head-up tilt test, detection of 24-h urinary sodium excretion, body mass index, midregional pro-adrenomedullin, and erythrocytic H2S producing rate are relatively stable, inexpensive, and easy to obtain. With the help of biomarkers, individualized treatment can be carried out to improve the long-term prognosis of children and adolescents with OI. This article reviews the prognostic value of biomarkers in children and adolescents with OI.

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