Nature Communications (Dec 2022)
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice
- Tatsuya Yoshizawa,
- Yoshifumi Sato,
- Shihab U. Sobuz,
- Tomoya Mizumoto,
- Tomonori Tsuyama,
- Md. Fazlul Karim,
- Keishi Miyata,
- Masayoshi Tasaki,
- Masaya Yamazaki,
- Yuichi Kariba,
- Norie Araki,
- Eiichi Araki,
- Shingo Kajimura,
- Yuichi Oike,
- Thomas Braun,
- Eva Bober,
- Johan Auwerx,
- Kazuya Yamagata
Affiliations
- Tatsuya Yoshizawa
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Yoshifumi Sato
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Shihab U. Sobuz
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Tomoya Mizumoto
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Tomonori Tsuyama
- Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University
- Md. Fazlul Karim
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Keishi Miyata
- Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University
- Masayoshi Tasaki
- Department of Neurology, Faculty of Life Sciences, Kumamoto University
- Masaya Yamazaki
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Yuichi Kariba
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- Norie Araki
- Department of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University
- Eiichi Araki
- Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University
- Shingo Kajimura
- Beth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute
- Yuichi Oike
- Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University
- Thomas Braun
- Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Eva Bober
- Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Johan Auwerx
- Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne
- Kazuya Yamagata
- Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University
- DOI
- https://doi.org/10.1038/s41467-022-35219-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Sirtuins have been reported to positively regulate brown adipose tissue thermogenesis. Here the authors report that brown adipocytic SIRT7 suppresses whole-body energy expenditure and thermogenesis in mice, potentially by attenuating batokine gene expressions and Ucp1 mRNA translation.
