Obesity Science & Practice (Aug 2024)

The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women

  • Ilaria Milani,
  • Chiara Gaita,
  • Gloria Guarisco,
  • Marianna Chinucci,
  • Roberta Parisella,
  • Silvia Piroli,
  • Eleonora Bruno,
  • Annunziata Martellucci,
  • Elena De Falco,
  • Fabio Ricci,
  • Antonella Calogero,
  • Frida Leonetti,
  • Danila Capoccia

DOI
https://doi.org/10.1002/osp4.786
Journal volume & issue
Vol. 10, no. 4
pp. n/a – n/a

Abstract

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Abstract Background Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC. Methods Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D. Results Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight (p 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.

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