Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up

DA Malatjalian; JB Ross; CN Williams; SJ Colwell; BJ Eastwood

doi:10.1155/1996/213596

Canadian Journal of Gastroenterology (Jan 1996)

Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up

DA Malatjalian,
JB Ross,
CN Williams,
SJ Colwell,
BJ Eastwood

Affiliations

DA Malatjalian: Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada
JB Ross: Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada
CN Williams: Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada
SJ Colwell: Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada
BJ Eastwood: Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, Canada

DOI: https://doi.org/10.1155/1996/213596
Journal volume & issue: Vol. 10, no. 6
pp. 369 – 375

Abstract

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BACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients received MTX over one to 11 years (mean 3.38), with baseline and annual follow-up liver biopsies. Clinical data were obtained by chart review. Statistical analysis evaluated the risks associated with obesity, diabetes, alcohol consumption and duration of therapy, with the histological grade of liver biopsies.

Published in Canadian Journal of Gastroenterology

ISSN: 0835-7900 (Print); 1916-7237 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/1720

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