Synthesis of monomers of γ-polyamide nucleic acids mimics

Abstract

Universal efficient preparative approach for obtaining of γ-substitued polyamide DNA-mimics on the base of L-alanine and L-glycine derivates was presented. As result of research cytosine and adenine-containing final monomers were synthesised. It was found that both allyl and methyl C-terminal protecting group can be used in the synthesis as example of cytosine-containing derivates.

Keywords

• peptide nucleic acids (pna)
• γ-substitued polyamides mimetics
• pseudopeptides
• mitsunobu reaction