Nature Communications (Oct 2022)
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice
- Wei Zhou,
- Wen-hui Wu,
- Zi-lin Si,
- Hui-ling Liu,
- Hanyu Wang,
- Hong Jiang,
- Ya-fang Liu,
- Raphael N. Alolga,
- Cheng Chen,
- Shi-jia Liu,
- Xue-yan Bian,
- Jin-jun Shan,
- Jing Li,
- Ning-hua Tan,
- Zhi-hao Zhang
Affiliations
- Wei Zhou
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Wen-hui Wu
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Zi-lin Si
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Hui-ling Liu
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Hanyu Wang
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Hong Jiang
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Ya-fang Liu
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Raphael N. Alolga
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Cheng Chen
- Department of Nephrology, Renmin Hospital of Wuhan University
- Shi-jia Liu
- Affiliated Hospital of Nanjing University of Chinese Medicine
- Xue-yan Bian
- Ningbo Hospital of Zhejiang University
- Jin-jun Shan
- Medical Metabolomics Center, Nanjing University of Chinese Medicine
- Jing Li
- School of Life Science and Technology, China Pharmaceutical University
- Ning-hua Tan
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Zhi-hao Zhang
- State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41467-022-33824-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.
