BMJ Open (Oct 2020)
Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)
- Saif Huda,
- Anu Jacob,
- Joachim Havla,
- Adriana Roca-Fernández,
- Philipp Albrecht,
- Maria Isabel Leite,
- Friedemann Paul,
- Alexander U Brandt,
- Jae-Won Hyun,
- Frederike Cosima Oertel,
- Claudia Chien,
- Nasrin Asgari,
- Elena H Martinez-Lapiscina,
- Orhan Aktas,
- Svenja Specovius,
- Hanna G Zimmermann,
- Charlotte Bereuter,
- Marco Aurélio Lana Peixoto,
- Mariana Andrade Fontenelle,
- Alejandro Rubio Diaz,
- Fereshte Ashtari,
- Rahele Kafieh,
- Alireza Dehghani,
- Mohsen Pourazizi,
- Lekha Pandit,
- Anitha Dcunha,
- Marius Ringelstein,
- Eugene May,
- Caryl Tongco,
- Marco Pisa,
- Marta Radaelli,
- Hadas Stiebel-Kalish,
- Mark Hellmann,
- Itay Lotan,
- Sasitorn Siritho,
- Jérôme de Seze,
- Thomas Senger,
- Caroline Tilikete,
- Alvaro Cobo Calvo,
- Denis Bernardi Bichuetti,
- Ivan Maynart Tavares,
- Kerstin Soelberg,
- Ayse Altintas,
- Rengin Yildirim,
- Uygur Tanriverdi,
- Zoe Rimler,
- Allyson Reid,
- Yang Mao-Draayer,
- Ibis Soto de Castillo,
- Michael R Yeaman,
- Terry J Smith
Affiliations
- Saif Huda
- Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK
- Anu Jacob
- Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK
- Joachim Havla
- 2 Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
- Adriana Roca-Fernández
- Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
- Philipp Albrecht
- 7 Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- Maria Isabel Leite
- 1 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
- Friedemann Paul
- 1 Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Alexander U Brandt
- 1 NeuroCure Clinical Research Center, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Jae-Won Hyun
- Department of Neurology, National Cancer Center, Goyang, Republic of Korea
- Frederike Cosima Oertel
- Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Claudia Chien
- Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Nasrin Asgari
- Departments of Neurology, Slagelse Hospital, Slagelse, Denmark
- Elena H Martinez-Lapiscina
- Hospital Clinic of Barcelona-Institut d’Investigacions, Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain
- Orhan Aktas
- Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- Svenja Specovius
- Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Hanna G Zimmermann
- Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Charlotte Bereuter
- Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Marco Aurélio Lana Peixoto
- CIEM MS Research Center, University of Minas Gerais, Medical School, Belo Horizonte, Brazil
- Mariana Andrade Fontenelle
- CIEM MS Research Center, University of Minas Gerais, Medical School, Belo Horizonte, Brazil
- Alejandro Rubio Diaz
- Department of Neurology, Oxford University Hospitals, National Health Service Trust, Oxford, UK
- Fereshte Ashtari
- Kashani MS Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Rahele Kafieh
- School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
- Alireza Dehghani
- Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Mohsen Pourazizi
- Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Lekha Pandit
- Department of Neurology, KS Hegde Medical Academy, Nitte University, Mangalore, India
- Anitha Dcunha
- Department of Neurology, KS Hegde Medical Academy, Nitte University, Mangalore, India
- Marius Ringelstein
- Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- Eugene May
- Swedish Neuroscience Institute Neuro-Ophthalmology, Seattle, Washington, USA
- Caryl Tongco
- Swedish Neuroscience Institute Neuro-Ophthalmology, Seattle, Washington, USA
- Marco Pisa
- Neurological Department and Institute of Experimental Neurology (INSPE) Scientific Institute, Hospital San Raffaele; and University Vita-Salute San Raffaele, Milan, Italy
- Marta Radaelli
- Neurological Department and Institute of Experimental Neurology (INSPE) Scientific Institute, Hospital San Raffaele; and University Vita-Salute San Raffaele, Milan, Italy
- Hadas Stiebel-Kalish
- Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
- Mark Hellmann
- Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
- Itay Lotan
- Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
- Sasitorn Siritho
- Division of Neurology, Department of Medicine, Siriraj Hospital and Bumrungrad International Hospital, Bangkok, Thailand
- Jérôme de Seze
- Neurology Service, University Hospital of Strasbourg, Strasbourg, France
- Thomas Senger
- Neurology Service, University Hospital of Strasbourg, Strasbourg, France
- Caroline Tilikete
- Department of Neuro-Ophthalmology, Hospices Civils de Lyon, Lyon, France
- Alvaro Cobo Calvo
- Neurology, Multiple Sclerosis, Myelin Disorders and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France
- Denis Bernardi Bichuetti
- Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
- Ivan Maynart Tavares
- Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
- Kerstin Soelberg
- Departments of Neurology, Slagelse Hospital, Slagelse, Denmark
- Ayse Altintas
- Neurology Department, School of Medicine, Koc University and Istanbul University - Cerrahpasa School of Medicine, Istanbul, Turkey
- Rengin Yildirim
- Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
- Uygur Tanriverdi
- Neurology Department Istanbul, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey
- Zoe Rimler
- Department of Neurology, NYU Multiple Sclerosis Comprehensive Care Center, NYU School of Medicine, New York, New York, USA
- Allyson Reid
- Department of Neurology, NYU Multiple Sclerosis Comprehensive Care Center, NYU School of Medicine, New York, New York, USA
- Yang Mao-Draayer
- Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
- Ibis Soto de Castillo
- Department of Neurology, Hospital Clínico de Maracaibo, Maracaibo, Venezuela
- Michael R Yeaman
- Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA
- Terry J Smith
- Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, Ann Arbor, Michigan, USA
- DOI
- https://doi.org/10.1136/bmjopen-2019-035397
- Journal volume & issue
-
Vol. 10,
no. 10
Abstract
Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD.Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices.Findings to date The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline.Future plans We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.
