Communications Biology (Jul 2021)
Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
- Tina Schumann,
- Jörg König,
- Christian von Loeffelholz,
- Daniel F. Vatner,
- Dongyan Zhang,
- Rachel J. Perry,
- Michel Bernier,
- Jason Chami,
- Christine Henke,
- Anica Kurzbach,
- Nermeen N. El-Agroudy,
- Diana M. Willmes,
- Dominik Pesta,
- Rafael de Cabo,
- John F. O´Sullivan,
- Eric Simon,
- Gerald I. Shulman,
- Bradford S. Hamilton,
- Andreas L. Birkenfeld
Affiliations
- Tina Schumann
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- Jörg König
- Clinical Pharmacology and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg
- Christian von Loeffelholz
- Department of Anaesthesiology and Intensive Care, Jena University Hospital
- Daniel F. Vatner
- Department of Internal Medicine, Yale School of Medicine
- Dongyan Zhang
- Department of Internal Medicine, Yale School of Medicine
- Rachel J. Perry
- Department of Internal Medicine, Yale School of Medicine
- Michel Bernier
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Jason Chami
- Heart Research Institute
- Christine Henke
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- Anica Kurzbach
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- Nermeen N. El-Agroudy
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- Diana M. Willmes
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- Dominik Pesta
- German Center for Diabetes Research (DZD)
- Rafael de Cabo
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- John F. O´Sullivan
- Heart Research Institute
- Eric Simon
- Computational Biology, Boehringer-Ingelheim Pharma GmbH & Co. KG
- Gerald I. Shulman
- Department of Internal Medicine, Yale School of Medicine
- Bradford S. Hamilton
- CardioMetabolic Diseases Research, Boehringer-Ingelheim Pharma GmbH & Co. KG
- Andreas L. Birkenfeld
- Section of Metabolic and Vascular Medicine, Medical Clinic III, Dresden University School of Medicine, Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s42003-021-02279-8
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 17
Abstract
Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease.
