Nature Communications (May 2020)
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
- Maikel L. Colli,
- Mireia Ramos-Rodríguez,
- Ernesto S. Nakayasu,
- Maria I. Alvelos,
- Miguel Lopes,
- Jessica L. E. Hill,
- Jean-Valery Turatsinze,
- Alexandra Coomans de Brachène,
- Mark A. Russell,
- Helena Raurell-Vila,
- Angela Castela,
- Jonàs Juan-Mateu,
- Bobbie-Jo M. Webb-Robertson,
- Lars Krogvold,
- Knut Dahl-Jorgensen,
- Lorella Marselli,
- Piero Marchetti,
- Sarah J. Richardson,
- Noel G. Morgan,
- Thomas O. Metz,
- Lorenzo Pasquali,
- Décio L. Eizirik
Affiliations
- Maikel L. Colli
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Mireia Ramos-Rodríguez
- Endocrine Regulatory Genomics, Department of Experimental & Health Sciences, University Pompeu Fabra
- Ernesto S. Nakayasu
- Biological Sciences Division, Pacific Northwest National Laboratory
- Maria I. Alvelos
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Miguel Lopes
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Jessica L. E. Hill
- Institute of Biomedical & Clinical Science, University of Exeter Medical School
- Jean-Valery Turatsinze
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Alexandra Coomans de Brachène
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Mark A. Russell
- Institute of Biomedical & Clinical Science, University of Exeter Medical School
- Helena Raurell-Vila
- Endocrine Regulatory Genomics, Department of Experimental & Health Sciences, University Pompeu Fabra
- Angela Castela
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Jonàs Juan-Mateu
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- Bobbie-Jo M. Webb-Robertson
- Biological Sciences Division, Pacific Northwest National Laboratory
- Lars Krogvold
- Division of Pediatric and Adolescent Medicine, Faculty of Medicine, Oslo University Hospital
- Knut Dahl-Jorgensen
- Division of Pediatric and Adolescent Medicine, Faculty of Medicine, Oslo University Hospital
- Lorella Marselli
- Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
- Piero Marchetti
- Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
- Sarah J. Richardson
- Institute of Biomedical & Clinical Science, University of Exeter Medical School
- Noel G. Morgan
- Institute of Biomedical & Clinical Science, University of Exeter Medical School
- Thomas O. Metz
- Biological Sciences Division, Pacific Northwest National Laboratory
- Lorenzo Pasquali
- Endocrine Regulatory Genomics, Department of Experimental & Health Sciences, University Pompeu Fabra
- Décio L. Eizirik
- ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles
- DOI
- https://doi.org/10.1038/s41467-020-16327-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression.
