Pharmaceuticals (May 2024)

Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin

  • Mateusz Kciuk,
  • Nitika Garg,
  • Sanchit Dhankhar,
  • Monika Saini,
  • Somdutt Mujwar,
  • Sushma Devi,
  • Samrat Chauhan,
  • Thakur Gurjeet Singh,
  • Randhir Singh,
  • Beata Marciniak,
  • Adrianna Gielecińska,
  • Renata Kontek

DOI
https://doi.org/10.3390/ph17060701
Journal volume & issue
Vol. 17, no. 6
p. 701

Abstract

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Neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and others) and cancer, seemingly disparate in their etiology and manifestation, exhibit intriguing associations in certain cellular and molecular processes. Both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and DNA repair and pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is a flavonoid compound abundant in various plant sources. Afzelin exhibits a diverse range of biological activities, offering promising prospects for the treatment of diseases hallmarked by oxidative stress and deregulation of cell death pathways. Its protective potential against oxidative stress is also promising for alleviating the side effects of chemotherapy. This review explores the potential therapeutic implications of afzelin, including its capacity to mitigate oxidative stress, modulate inflammation, and promote cellular regeneration in neurodegenerative and cancer diseases.

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