Nature Communications (May 2019)

Airway response to respiratory syncytial virus has incidental antibacterial effects

  • Charles J. Sande,
  • James M. Njunge,
  • Joyce Mwongeli Ngoi,
  • Martin N. Mutunga,
  • Timothy Chege,
  • Elijah T. Gicheru,
  • Elizabeth M. Gardiner,
  • Agnes Gwela,
  • Christopher A. Green,
  • Simon B. Drysdale,
  • James A. Berkley,
  • D. James Nokes,
  • Andrew J. Pollard

DOI
https://doi.org/10.1038/s41467-019-10222-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Respiratory syncytial virus (RSV) can trigger secondary airway bacterial infections. Here, by proteomics and metagenomics analyses of samples from Kenyan children, the authors report that RSV associates with Streptococcus burden and a local upper airway response with direct antibacterial properties.