Imunnological status in patients whis type 2 diabetes mellitus

Abstract

Aim. To elucidate peculiarities of autorosette formation (ARF), immunological status and associated factors in patients with type 2 diabetes mellitus. Materials and methods. The study included 148 patients with DM2 and 63 practically healthy subjects. The following parameters were measured:the number of autorosettes in peripheral blood, C-reactive protein level, and humoral immunity (from blood immunoglobulin levels); spontaneousand induced TNB tests were performed. Results. Patients with DM2 suffered disturbances of carbohydrate metabolism and had an elevated number of autorosettes in peripheral blood, dysimmunoglobulinemia,increased level of acute phase protein, impaired functional activity of neutrophils. Conclusion. Intensity of ARF increases with duration of DM2 and a rise in AP. Patients with long-standing severe DM2, AH, micro- and macroalbuminurea,hyperglycemia, and triglyceridemia experience deterioration of immunological status.

Keywords

• type 2 diabetes mellitus
• immune status
• endogenous autorosette formation