Assessment of vitamin D levels in association with clinical determinants in females with hip fracture.

Abstract

Background:Vitamin D deficiency is associated with an increased risk of falls and hip fractures in older adults. Risk factors are suboptimal sunlight exposure and the lower cutaneous synthesis of vitamin D, reduced dietary intake of D2 (ergocalciferol) and D3 (cholecalciferol), impaired intestinal absorption, and impaired hydroxylation in the liver and kidneys. The present study's objective was to determine the frequency of vitamin D levels in females with hip fractures presenting to a tertiary care facility in Karachi, Pakistan.Methodology:Across-sectional studywas conducted atthe Orthopaedic SurgeryDepartment of Jinnah Postgraduate Medical Center, Karachi, from 17thMay to 16thNovember 2016. A total of 123 females with Hip fracture of ≤ 4 weeks were includedin this study. Patient's age, occupation, education level, and comorbidities like diabetes mellitus(DM), hypertension(HTN), and Vitamin D levels were observed. The patient was labeled withvitamin D sufficiency, insufficiency, and deficiencyon the basis of Vitamin D levels. Stratification was done, and the post-stratification Chi-square test was applied.Results:The mean age of study participant was 60.32±9.14 yearsand the mean duration of fracture was 12.27±5.84 days, Body Mass Index (BMI)was 24.57±2.77 kg/m2, vitamin D level was 18.28±8.10 ng/ml. Only 8.9% were found with sufficient vitamin D levels. Insufficiency was found in 28.5% of patients. Vitamin D deficiency was found in 62.6% of patients. Conclusion:Vitamin D deficiencyis common in elderly female patients with hip fractures and is associated with age and DM. This initial work warrants further larger-scale studies of vitamin D variations.

Keywords

• vitamin d
• hip fracture
• orthopaedic
• diabetes mellitus