Nature Communications (Sep 2019)
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
- Tianxiao Huan,
- Roby Joehanes,
- Ci Song,
- Fen Peng,
- Yichen Guo,
- Michael Mendelson,
- Chen Yao,
- Chunyu Liu,
- Jiantao Ma,
- Melissa Richard,
- Golareh Agha,
- Weihua Guan,
- Lynn M. Almli,
- Karen N. Conneely,
- Joshua Keefe,
- Shih-Jen Hwang,
- Andrew D. Johnson,
- Myriam Fornage,
- Liming Liang,
- Daniel Levy
Affiliations
- Tianxiao Huan
- The Framingham Heart Study
- Roby Joehanes
- The Framingham Heart Study
- Ci Song
- The Framingham Heart Study
- Fen Peng
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Yichen Guo
- Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University
- Michael Mendelson
- The Framingham Heart Study
- Chen Yao
- The Framingham Heart Study
- Chunyu Liu
- Department of Biostatistics, Boston University School of Public Health
- Jiantao Ma
- The Framingham Heart Study
- Melissa Richard
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Golareh Agha
- Mailman School of Public Health, Columbia University
- Weihua Guan
- Division of Biostatistics, School of Public Health, University of Minnesota
- Lynn M. Almli
- Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine
- Karen N. Conneely
- Department of Human Genetics, Emory University School of Medicine
- Joshua Keefe
- The Framingham Heart Study
- Shih-Jen Hwang
- The Framingham Heart Study
- Andrew D. Johnson
- The Framingham Heart Study
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Liming Liang
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University
- Daniel Levy
- The Framingham Heart Study
- DOI
- https://doi.org/10.1038/s41467-019-12228-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.
