mBio (Apr 2021)

Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34 <sup>+</sup> Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome

  • Nicole L. Diggins,
  • Lindsey B. Crawford,
  • Meaghan H. Hancock,
  • Jennifer Mitchell,
  • Jay A. Nelson

DOI
https://doi.org/10.1128/mBio.00621-21
Journal volume & issue
Vol. 12, no. 2

Abstract

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Each herpesvirus family establishes latency in a unique cell type. Since herpesviruses genomes are maintained as episomes, the viruses need to devise mechanisms to retain the latent genome during cell division.