Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Junchen Liu; Ransome van der Hoeven; Walaa E. Kattan; Jeffrey T. Chang; Dina Montufar-Solis; Wei Chen; Maurice Wong; Yong Zhou; Carlito B. Lebrilla; John F. Hancock

doi:10.1038/s41467-023-36128-5

Nature Communications (Jan 2023)

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Junchen Liu,
Ransome van der Hoeven,
Walaa E. Kattan,
Jeffrey T. Chang,
Dina Montufar-Solis,
Wei Chen,
Maurice Wong,
Yong Zhou,
Carlito B. Lebrilla,
John F. Hancock

Affiliations

Junchen Liu: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Ransome van der Hoeven: Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston
Walaa E. Kattan: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Jeffrey T. Chang: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Dina Montufar-Solis: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Wei Chen: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Maurice Wong: Department of Chemistry, University of California
Yong Zhou: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Carlito B. Lebrilla: Department of Chemistry, University of California
John F. Hancock: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

DOI: https://doi.org/10.1038/s41467-023-36128-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

Read online

KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for KRAS oncogenesis that may have therapeutic potential.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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