Antimicrobial sesquiterpenoids from Laurencia obtusa Lamouroux

Bawakid Nahed O.; Alarif Walied M.; Alorfi Hajer S.; Al-Footy Khalid O.; Alburae Najla A.; Ghandourah Mohamed A.; Al-Lihaibi Sultan S.; Abdul-hameed Zainab H.

doi:10.1515/chem-2017-0025

Open Chemistry (Oct 2017)

Antimicrobial sesquiterpenoids from Laurencia obtusa Lamouroux

Bawakid Nahed O.,
Alarif Walied M.,
Alorfi Hajer S.,
Al-Footy Khalid O.,
Alburae Najla A.,
Ghandourah Mohamed A.,
Al-Lihaibi Sultan S.,
Abdul-hameed Zainab H.

Affiliations

Bawakid Nahed O.: Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah21589, Saudi Arabia
Alarif Walied M.: Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box 80207, Jeddah21589, Saudi Arabia
Alorfi Hajer S.: Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah21589, Saudi Arabia
Al-Footy Khalid O.: Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah21589, Saudi Arabia
Alburae Najla A.: Department of Biology, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah21589, Saudi Arabia
Ghandourah Mohamed A.: Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box 80207, Jeddah21589, Saudi Arabia
Al-Lihaibi Sultan S.: Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box 80207, Jeddah21589, Saudi Arabia
Abdul-hameed Zainab H.: Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah21589, Saudi Arabia

DOI: https://doi.org/10.1515/chem-2017-0025
Journal volume & issue: Vol. 15, no. 1
pp. 219 – 224

Abstract

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Purification of the organic extract of Laurencia obtusa Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol (1)], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde (2)], and two nor-cuparanes [3-hydroxy-15-nor-cuparan-10β-ol (3) and 2-bromo-3-hydroxy-15-nor-cuparan-10β-ol (4)]. Structural identification was made possible by comparison of spectral data with those reported in the literature. Compounds 3 and 4 are significant as nor-cuparanes are rarely isolated from marine environment. 1 showed moderate anticandidal activity, whereas 2 exhibited reasonable antibacterial activity against multidrug-resistant bacteria (especially Gram-positive). All the compounds are nontoxic to Artemia salina.

Published in Open Chemistry

ISSN: 2391-5420 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry
Website: https://www.degruyter.com/journal/key/CHEM/html

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