Известия высших учебных заведений. Поволжский регион: Медицинские науки (Jun 2022)
Evaluation of the effect of glomerular filtration rate on the life quality of geriatric patients with arterial hypertension
Abstract
Background. The problem of geriatric patients is becoming more acute as the population in Russia ages. Also, an increase in middle age is accompanied by an increase in the number of patients with chronic kidney disease, which is due to both comorbid cardiovascular pathology, in particular arterial hypertension, and physiological age-related nephroangiosclerosis. Thus, all of the above highlights the relevance of studying the effect of glomerular filtration rate on the quality of life of geriatric patients with arterial hypertension, which is the purpose of this study. Materials and methods. 274 patients with arterial hypertension (AH) over 65 years of age were selected for the study. In this sample, the prevalence of the syndrome of SA, preasthenia was determined, and a group of people without geriatric disorders was also formed. Further, in each of the three groups (CA, preasthenia, absence of geriatric disorders), 2 subgroups of patients were formed – in 1 subgroup, the GFR level was more than 60 ml/min, in 2 – less than 60 ml/min. After that, QOL was assessed in all subgroups based on the SF-36 questionnaire. Results. CA syndrome was diagnosed in 40.9 % of patients, preasthenia was detected in 35.0 % of cases, and geriatric profile disorders were not identified in 24.1 %. With a decrease in GFR of less than 60 ml/min, patients with CA and AH syndrome note a deterioration exclusively in the indicators of the physical status of PF, RP, GH. The results in the preasthenia group are similar to the CA syndrome group on all scales, with the exception of role-based physical functioning. In the group of patients with hypertension without signs of geriatric disorders with a decrease in GFR of less than 60 ml/min, a significant difference in QOL indicators was determined only on the PF scale. Conclusions. The prevalence of CA syndrome in patients with arterial hypertension is 40.9 %. With a decrease in GFR of less than 60 ml/min, patients with CA and AH syndrome note a deterioration exclusively in physical status indicators. The results in the preasthenia group are similar to the CA syndrome group on all scales, with the exception of role-based physical functioning. Thus, the data obtained indicate that timely nephroprotective therapy provides prevention of a decrease in the indicators of the physical status of QOL in patients with CA and hypertension.
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