Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

Hao-Lian Wang; Yan Chen; Yun-Qian Wang; En-Wei Tao; Juan Tan; Qian-Qian Liu; Chun-Min Li; Xue-Mei Tong; Qin-Yan Gao; Jie Hong; Ying-Xuan Chen; Jing-Yuan Fang

doi:10.1038/s41467-022-33903-8

Nature Communications (Oct 2022)

Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

Hao-Lian Wang,
Yan Chen,
Yun-Qian Wang,
En-Wei Tao,
Juan Tan,
Qian-Qian Liu,
Chun-Min Li,
Xue-Mei Tong,
Qin-Yan Gao,
Jie Hong,
Ying-Xuan Chen,
Jing-Yuan Fang

Affiliations

Hao-Lian Wang: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Yan Chen: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Yun-Qian Wang: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
En-Wei Tao: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Juan Tan: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Qian-Qian Liu: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Chun-Min Li: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Xue-Mei Tong: Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
Qin-Yan Gao: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Jie Hong: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Ying-Xuan Chen: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Jing-Yuan Fang: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-022-33903-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Sirtuin 5 (SIRT5) has been associated to colorectal cancer and metabolic regulation. Here, the authors show that SIRT5 silencing reduces nucleotide availability leading to DNA damage and tumor suppression in colorectal cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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