Nature Communications (Feb 2019)
Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells
- Min Cheng,
- Junjie Yang,
- Xiaoqi Zhao,
- Eric Zhang,
- Qiutang Zeng,
- Yang Yu,
- Liu Yang,
- Bangwei Wu,
- Guiwen Yi,
- Xiaobo Mao,
- Kai Huang,
- Nianguo Dong,
- Min Xie,
- Nita A. Limdi,
- Sumanth D. Prabhu,
- Jianyi Zhang,
- Gangjian Qin
Affiliations
- Min Cheng
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Junjie Yang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Xiaoqi Zhao
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Eric Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Qiutang Zeng
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Yang Yu
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Liu Yang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Bangwei Wu
- Department of Cardiology, Huashan Hospital, Fudan University
- Guiwen Yi
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiaobo Mao
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Kai Huang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Nianguo Dong
- Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Min Xie
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, School of Medicine
- Nita A. Limdi
- Department of Neurology and Epidemiology, University of Alabama at Birmingham, School of Medicine
- Sumanth D. Prabhu
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, School of Medicine
- Jianyi Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- Gangjian Qin
- Department of Biomedical Engineering, University of Alabama at Birmingham, School of Medicine and School of Engineering
- DOI
- https://doi.org/10.1038/s41467-019-08895-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
During myocardial infarction, microRNAs (myo-miRs) are released into the circulation. Here Cheng et al. show that myo-miRs carried in exosomes are transferred to the bone marrow (BM), downregulate expression of CXCR4 in mononuclear cells, and increase the number of circulating BM progenitor cells, thus orchestrating a systemic response to myocardial injury.
