Nature Communications (Oct 2021)

Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus

  • Jennifer A. E. Payne,
  • Julien Tailhades,
  • Felix Ellett,
  • Xenia Kostoulias,
  • Alex J. Fulcher,
  • Ting Fu,
  • Ryan Leung,
  • Stephanie Louch,
  • Amy Tran,
  • Severin A. Weber,
  • Ralf B. Schittenhelm,
  • Graham J. Lieschke,
  • Chengxue Helena Qin,
  • Daniel Irima,
  • Anton Y. Peleg,
  • Max J. Cryle

DOI
https://doi.org/10.1038/s41467-021-26244-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Antibiotic resistance in Staphylococcus aureus is associated with reduced neutrophil recruitment. Here, Payne et al. link formylated peptides, which act as chemoattractants for neutrophils, with the antibiotic vancomycin and show that these hybrid compounds improve clearance of S. aureus by neutrophils.