Acta Biomedica Scientifica (May 2012)

PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

  • A. A. Koshkina,
  • V. V. Novitskij,
  • O. I. Urazova,
  • I. E. Esimova,
  • R. R. Hasanova

Journal volume & issue
Vol. 0, no. 3(2)
pp. 92 – 95

Abstract

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The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in the total amount of CD3-positive cells and suppression of IL-2- secretion during CD3/CD28-induction of lymphocytes, which was most expressed in a disseminated form of drug-resistant TB. We also demonstrated the reduction in the percentage value of CD3+CD28+IL-2+ and CD3+CD28+IL-2- cells in patients with pulmonary TB against the background of the increase in the percentage value of CD3+CD28-IL-2-. Besides, it was also shown that the detected changes are unidirectional, don't depend on a clinical form of TB and are maximally manifested in patients with a drug resistant variant of the TB process.

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