Angiogenesis as an adaptive mechanism in ischemia

Abstract

The article is devoted to angiogenesis as one of the ways to increase the stability of the ischemic tissue. It is shown that the reduction in ischemic tissue damage is based on four basic processes - vasculogenesis of endothelial progenitor cells, angiogenesis and arteriogenesis with the growth and subsequent stabilization of the outgrowths of mural cells and the growth of collaterals (expansive growth of pre-existing vessels). However, despite the great progress in the understanding of ischemia-induced angiogenesis, and a lot of positive results from its stimulation using the disclosed arrangements natural response to the reduction of tissue perfusion is still an unsolved problem is the practical use of this knowledge to improve the metabolic processes of organs and tissues with compromised vascular bed. The effect of a variety of recombinant growth factors is not enough long-term, and besides, is not without serious side effects. From this perspective, the greatest opportunities is the development of techniques using natural pool of pluripotent cells with high angiogenic potential.

Keywords

• ischemia
• angiogenesis
• growth factors
• pluripotent cells