Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Yung-Chih Chen; Meaghan Smith; Ya-Lan Ying; Manousos Makridakis; Jonathan Noonan; Peter Kanellakis; Alin Rai; Agus Salim; Andrew Murphy; Alex Bobik; Antonia Vlahou; David W. Greening; Karlheinz Peter

doi:10.1038/s42003-023-04641-4

Communications Biology (Mar 2023)

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Yung-Chih Chen,
Meaghan Smith,
Ya-Lan Ying,
Manousos Makridakis,
Jonathan Noonan,
Peter Kanellakis,
Alin Rai,
Agus Salim,
Andrew Murphy,
Alex Bobik,
Antonia Vlahou,
David W. Greening,
Karlheinz Peter

Affiliations

Yung-Chih Chen: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Meaghan Smith: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Ya-Lan Ying: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Manousos Makridakis: Proteomics Research Unit, Biotechnology Division, Biomedical Research Foundation of the Academy of Athens
Jonathan Noonan: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Peter Kanellakis: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Alin Rai: Department of Cardiometabolic Health, University of Melbourne
Agus Salim: Department of Bioinformatics, Baker Heart and Diabetes Institute
Andrew Murphy: Central Clinical School, Monash University
Alex Bobik: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute
Antonia Vlahou: Proteomics Research Unit, Biotechnology Division, Biomedical Research Foundation of the Academy of Athens
David W. Greening: Central Clinical School, Monash University
Karlheinz Peter: Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute

DOI: https://doi.org/10.1038/s42003-023-04641-4
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 11

Abstract

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Protein signatures of unstable and stable atherosclerosis are defined by quantitative proteomics using a preclinical mouse model of plaque instability/rupture.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal