Evaluation of the Effect of Intravenous and Intraperitoneal Lidocaine on Pain Intensity in Comparison to Control Group in Laparoscopic Cholecystectomy

Abstract

Background: Postsurgical pain is one of the complications that can affect patient's life negatively. The aim of this study was to evaluate the effect of intravenous lidocaine in comparison to intraperitoneal lidocaine on postsurgical pain in laparoscopic cholecystectomy. Methods: This was a randomized, double-blind clinical trial study on96 patients who underwent laparoscopic cholecystectomy in Alzahra hospital, Isfahan, Iran in 2013-2014. Patients with American Society of Anesthesiologists (ASA) physical status of I and II considered to undergo laparoscopic cholecystectomy were divided into 3 groups of control, intravenous lidocaine, and intraperitoneal lidocaine. Collected data were analyzed using Kruskal-Wallis, ANOVA, and chi-square tests via SPSS software. P value of less than 0.050 was considered significant. Findings: Mean pain intensity based on visual analogue scale (VAS) was considerably higher in control group in comparison to two others (P < 0.050 for both). In addition, mean dose of postsurgical pethidine administration was significantly higher in control group (P < 0.001). Conclusion: This study showed that intravenous and intraperitoneal lidocaine can reduce postsurgical pain intensity, and pethidine administration in laparoscopic cholecystectomy.

Keywords

• Intravenous
• Intraperitoneal
• Lidocaine
• Laparoscopic Cholecystectomy
• Postoperative pain