Nature Communications (Mar 2017)

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis

  • Christian Barthels,
  • Ana Ogrinc,
  • Verena Steyer,
  • Stefanie Meier,
  • Ferdinand Simon,
  • Maria Wimmer,
  • Andreas Blutke,
  • Tobias Straub,
  • Ursula Zimber-Strobl,
  • Esther Lutgens,
  • Peggy Marconi,
  • Caspar Ohnmacht,
  • Debora Garzetti,
  • Bärbel Stecher,
  • Thomas Brocker

DOI
https://doi.org/10.1038/ncomms14715
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

CD103+ dendritic cells induce iTreg cells to maintain immune balance in the gut, but how CD40-signalling regulates this process is unclear. Here the authors show that mice with constitutive CD11c-specific CD40-signalling have altered CD103+dendritic cell migration, reduced iTreg cell induction, and fatal colitis.