The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients

Abstract

This study aims to analyse the results of specific IgE to molecular components of PR 10 proteins, mould and yeast in atopic dermatitis (AD) patients, to find significant sets of molecular components in pairs and triplets in the relation to the severity of atopic dermatitis and the occurrence of asthma bronchiale and allergic rhinitis. The examination of the sensitization to molecular components with ALEX2 Allergy Explorer testing was performed. The level of specific IgE was recorded with Jittered box plots, the Kruskal–Wallis test was used to compare the level of specific IgE in different forms of AD. The relation between the results of specific IgE was evaluated with Coefficient of correlation (Kendall tau-b). The comparison of significant rules was performed with Fisher–Freeman–Halton exact test and with tests on proportions. Altogether 100 atopic dermatitis patients were examined. Molecular components Fra a 1 + 3, Mal d 1, Api g 1, Mala s 11 and Asp f 6 are recorded as a single molecular component with relation to the severe form of AD; these components are associated in pairs and triplets with molecular components Cor a 1.0401, Cor a 1.0103, Fag s 1, Alt a 1 and with the occurrence of allergic rhinitis. Results are presented in static and interactive tables and plots.

Keywords

• Atopic dermatitis
• ALEX2 Allergy explorer
• molecular components
• severity of atopic dermatitis
• disturbed epidermal barrier
• asthma bronchiale