An Infection-Tolerant Mammalian Reservoir for Several Zoonotic Agents Broadly Counters the Inflammatory Effects of Endotoxin

Gabriela Balderrama-Gutierrez; Ana Milovic; Vanessa J. Cook; M. Nurul Islam; Youwen Zhang; Hippokratis Kiaris; John T. Belisle; Ali Mortazavi; Alan G. Barbour

doi:10.1128/mBio.00588-21

mBio (Apr 2021)

An Infection-Tolerant Mammalian Reservoir for Several Zoonotic Agents Broadly Counters the Inflammatory Effects of Endotoxin

Gabriela Balderrama-Gutierrez,
Ana Milovic,
Vanessa J. Cook,
M. Nurul Islam,
Youwen Zhang,
Hippokratis Kiaris,
John T. Belisle,
Ali Mortazavi,
Alan G. Barbour

Affiliations

Gabriela Balderrama-Gutierrez: ORCiD; Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, California, USA
Ana Milovic: ORCiD; Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, California, USA
Vanessa J. Cook: ORCiD; Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, California, USA
M. Nurul Islam: ORCiD; Department of Microbiology, Immunology, & Pathology, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
Youwen Zhang: ORCiD; Department of Drug Discovery & Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA
Hippokratis Kiaris: ORCiD; Peromyscus Genetic Stock Center, University of South Carolina, Columbia, South Carolina, USA
John T. Belisle: ORCiD; Department of Microbiology, Immunology, & Pathology, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
Ali Mortazavi: ORCiD; Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, California, USA
Alan G. Barbour: ORCiD; Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, California, USA

DOI: https://doi.org/10.1128/mBio.00588-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Animals that are natural carriers of pathogens that cause human diseases commonly manifest little or no sickness as a consequence of infection. Examples include the deer mouse, Peromyscus leucopus

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal