Nature Communications (Sep 2020)
Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring
- Na Sun,
- Yi-Te Lee,
- Ryan Y. Zhang,
- Rueihung Kao,
- Pai-Chi Teng,
- Yingying Yang,
- Peng Yang,
- Jasmine J. Wang,
- Matthew Smalley,
- Pin-Jung Chen,
- Minhyung Kim,
- Shih-Jie Chou,
- Lirong Bao,
- Jing Wang,
- Xinyue Zhang,
- Dongping Qi,
- Juvelyn Palomique,
- Nicolas Nissen,
- Steven-Huy B. Han,
- Saeed Sadeghi,
- Richard S. Finn,
- Sammy Saab,
- Ronald W. Busuttil,
- Daniela Markovic,
- David Elashoff,
- Hsiao-hua Yu,
- Huiying Li,
- Anthony P. Heaney,
- Edwin Posadas,
- Sungyong You,
- Ju Dong Yang,
- Renjun Pei,
- Vatche G. Agopian,
- Hsian-Rong Tseng,
- Yazhen Zhu
Affiliations
- Na Sun
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Yi-Te Lee
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Ryan Y. Zhang
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Rueihung Kao
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Pai-Chi Teng
- Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Yingying Yang
- Department of Medicine, David Geffen School of Medicine, University of California
- Peng Yang
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Jasmine J. Wang
- Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Matthew Smalley
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Pin-Jung Chen
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Minhyung Kim
- Division of Cancer Biology and Therapeutics, Departments of Surgery, Cedars-Sinai Medical Center
- Shih-Jie Chou
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Lirong Bao
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Jing Wang
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Xinyue Zhang
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Dongping Qi
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Juvelyn Palomique
- Comprehensive Transplant Center, Cedars-Sinai Medical Center
- Nicolas Nissen
- Comprehensive Transplant Center, Cedars-Sinai Medical Center
- Steven-Huy B. Han
- Department of Medicine, David Geffen School of Medicine, University of California
- Saeed Sadeghi
- Department of Medicine, David Geffen School of Medicine, University of California
- Richard S. Finn
- Department of Medicine, David Geffen School of Medicine, University of California
- Sammy Saab
- Department of Medicine, David Geffen School of Medicine, University of California
- Ronald W. Busuttil
- Department of Surgery, David Geffen School of Medicine, University of California
- Daniela Markovic
- Department of Medicine, Statistics Core, David Geffen School of Medicine, University of California
- David Elashoff
- Department of Medicine, Statistics Core, David Geffen School of Medicine, University of California
- Hsiao-hua Yu
- Smart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica
- Huiying Li
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Anthony P. Heaney
- Department of Medicine, David Geffen School of Medicine, University of California
- Edwin Posadas
- Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Sungyong You
- Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Ju Dong Yang
- Comprehensive Transplant Center, Cedars-Sinai Medical Center
- Renjun Pei
- Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Vatche G. Agopian
- Department of Surgery, David Geffen School of Medicine, University of California
- Hsian-Rong Tseng
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- Yazhen Zhu
- California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California
- DOI
- https://doi.org/10.1038/s41467-020-18311-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Extracellular vesicles (EVs) are present in circulation at relatively early stages of disease, providing potential opportunities for early cancer diagnosis. Here, the authors report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific EV purification system for early detection of HCC by performing digital scoring on the purified EVs.
