Nature Communications (Jun 2020)
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
- Yuyoung Joo,
- Yutong Xue,
- Yue Wang,
- Ross A. McDevitt,
- Nirnath Sah,
- Simone Bossi,
- Shuaikun Su,
- Seung Kyu Lee,
- Wei Peng,
- Aoji Xie,
- Yongqing Zhang,
- Yi Ding,
- Wai Lim Ku,
- Soumita Ghosh,
- Kenneth Fishbein,
- Weiping Shen,
- Richard Spencer,
- Kevin Becker,
- Keji Zhao,
- Mark P. Mattson,
- Henriette van Praag,
- Alexei Sharov,
- Weidong Wang
Affiliations
- Yuyoung Joo
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yutong Xue
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yue Wang
- Neuroscience, National Institute on Aging, National Institutes of Health
- Ross A. McDevitt
- The Comparative Medicine Section, National Institute on Aging, National Institutes of Health
- Nirnath Sah
- Neuroscience, National Institute on Aging, National Institutes of Health
- Simone Bossi
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Shuaikun Su
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Seung Kyu Lee
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Wei Peng
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Aoji Xie
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yongqing Zhang
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yi Ding
- Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health
- Wai Lim Ku
- Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health
- Soumita Ghosh
- Clinical Investigation, National Institute on Aging, National Institutes of Health
- Kenneth Fishbein
- Clinical Investigation, National Institute on Aging, National Institutes of Health
- Weiping Shen
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Richard Spencer
- Clinical Investigation, National Institute on Aging, National Institutes of Health
- Kevin Becker
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Keji Zhao
- Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health
- Mark P. Mattson
- Neuroscience, National Institute on Aging, National Institutes of Health
- Henriette van Praag
- Neuroscience, National Institute on Aging, National Institutes of Health
- Alexei Sharov
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Weidong Wang
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-16884-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity.
