RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis

Gyles Ifill; Travis Blimkie; Amy Huei-Yi Lee; George A. Mackie; Qing Chen; Scott Stibitz; Robert E. W. Hancock; Rachel C. Fernandez

doi:10.1128/mSphere.00650-21

mSphere (Aug 2021)

RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis

Gyles Ifill,
Travis Blimkie,
Amy Huei-Yi Lee,
George A. Mackie,
Qing Chen,
Scott Stibitz,
Robert E. W. Hancock,
Rachel C. Fernandez

Affiliations

Gyles Ifill: Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Travis Blimkie: Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Amy Huei-Yi Lee: Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
George A. Mackie: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Qing Chen: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
Scott Stibitz: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
Robert E. W. Hancock: ORCiD; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Rachel C. Fernandez: ORCiD; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

DOI: https://doi.org/10.1128/mSphere.00650-21
Journal volume & issue: Vol. 6, no. 4

Abstract

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Noncoding, regulatory RNAs in bacterial pathogens are critical components required for rapid changes in gene expression profiles. However, little is known about the role of regulatory RNAs in the growth and pathogenesis of Bordetella pertussis

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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