Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties

Irina Chikalovets; Alina Filshtein; Valentina Molchanova; Tatyana Mizgina; Pavel Lukyanov; Olga Nedashkovskaya; Kuo-Feng Hua; Oleg Chernikov

doi:10.3390/molecules25010150

Molecules (Dec 2019)

Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties

Irina Chikalovets,
Alina Filshtein,
Valentina Molchanova,
Tatyana Mizgina,
Pavel Lukyanov,
Olga Nedashkovskaya,
Kuo-Feng Hua,
Oleg Chernikov

Affiliations

Irina Chikalovets: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Alina Filshtein: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Valentina Molchanova: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Tatyana Mizgina: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Pavel Lukyanov: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Olga Nedashkovskaya: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Kuo-Feng Hua: Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan
Oleg Chernikov: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia

DOI: https://doi.org/10.3390/molecules25010150
Journal volume & issue: Vol. 25, no. 1
p. 150

Abstract

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A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting β-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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