Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis

Caitlin R. Francis; Hayle Kincross; Erich J. Kushner

doi:10.1038/s41467-022-32853-5

Nature Communications (Sep 2022)

Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis

Caitlin R. Francis,
Hayle Kincross,
Erich J. Kushner

Affiliations

Caitlin R. Francis: Department of Biological Sciences, University of Denver
Hayle Kincross: Department of Biological Sciences, University of Denver
Erich J. Kushner: Department of Biological Sciences, University of Denver

DOI: https://doi.org/10.1038/s41467-022-32853-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The promiscuous GTPase Rab35 has been shown to be involved in many important cellular functions. In this article, Francis et al. illustrate how Rab35 acts as a critical brake to actin remodeling during sprouting angiogenesis and how it is necessary for proper blood vessel development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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