Communications Biology (Dec 2021)

Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner

  • Xihua Yue,
  • Neeraj Tiwari,
  • Lianhui Zhu,
  • Hai Dang Truong Ngo,
  • Jae-Min Lim,
  • Bopil Gim,
  • Shuaiyang Jing,
  • Yijing Wang,
  • Yi Qian,
  • Intaek Lee

DOI
https://doi.org/10.1038/s42003-021-02899-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Xihua Yue et al. report that Tankyrase-1 controls poly-ADP-ribosylation of Golgin45, a Golgi structural protein, which has a profound influence on glycosyltransferase trafficking and protein glycosylation at the Golgi. This may shed new light onto mechanisms involved in development and oncogenic transformation.