Some considerations about debugging a genome - scale metabolic models ba sed on computational algorithms

Abstract

The development of molecular biology has allowed rapid progress in understanding the functions and principles of operation of cells and unicellular organisms at the molecular level. One of the new areas of research that emerges from this picture is Systems Biology, having as one of its reconstruction of genome - scale metabolic models cornerstones. Currently, this reconstruction is a complex issue, because basically it is not automated. Consequently, this paper attempts to make some considerations about debugging a genomic scale metabolic models based on computational algorithms, an intention that has a high methodological value, how to make possible a major social problem.

Keywords

• Biología de Sistemas
• Reconstrucción de modelos metabólicos.