Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Guha Asthagiri Arunkumar; Disha Bhavsar; Tiehai Li; Shirin Strohmeier; Veronika Chromikova; Fatima Amanat; Mehman Bunyatov; Patrick C. Wilson; Ali H. Ellebedy; Geert-Jan Boons; Viviana Simon; Robert P. de Vries; Florian Krammer

doi:10.1038/s41467-021-26409-2

Nature Communications (Oct 2021)

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Guha Asthagiri Arunkumar,
Disha Bhavsar,
Tiehai Li,
Shirin Strohmeier,
Veronika Chromikova,
Fatima Amanat,
Mehman Bunyatov,
Patrick C. Wilson,
Ali H. Ellebedy,
Geert-Jan Boons,
Viviana Simon,
Robert P. de Vries,
Florian Krammer

Affiliations

Guha Asthagiri Arunkumar: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Disha Bhavsar: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Tiehai Li: Complex Carbohydrate Research Center, University of Georgia
Shirin Strohmeier: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Veronika Chromikova: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Fatima Amanat: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Mehman Bunyatov: Department of Chemical Biology and Drug Discovery, Utrecht University
Patrick C. Wilson: Departmentof Medicine, University of Chicago
Ali H. Ellebedy: Department of Pathology and Immunology, Washington University School of Medicine
Geert-Jan Boons: Complex Carbohydrate Research Center, University of Georgia
Viviana Simon: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Robert P. de Vries: Department of Chemical Biology and Drug Discovery, Utrecht University
Florian Krammer: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-26409-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The recently identified Wuhan spiny eel influenza virus (WSEIV) sequence is more closely related to influenza B than A viruses. Here, the authors functionally characterize the putative surface glycoproteins of WSEIV and show that its NA-like protein has sialidase activity and its HA-like protein binds monosialic ganglioside 2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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