On the use of aqueous solutions of polyvinyl methyl ether for the embolization of blood vessels

Abstract

Aqueous solutions of polyvinyl methyl ether were investigated in order to test whether it is possible to utilize them as bases for embolic agents used to deliberately block blood vessels. This may be necessary in the course of treatment of vascular abnormalities, tumors, as well as during the preparation of patients for surgery. The right branch of the binodal curve for the binary system “polyvinyl methyl ether–water” was drawn using the cloud point method and the lower critical mixing temperature (35.5 °C) was calculated. Furthermore, the exact concentration of polyvinyl methyl ether in aqueous solutions at which phase transition occurs (given the temperature of 35.5 °C) was found to be 30 wt %. The viscosity–velocity curves for the 30% solution of polyvinyl methyl ether, obtained by rheoviscometry in the temperature range of 5 to 36 °C, indicate that this aqueous solution has a low viscosity and behaves like a Newtonian fluid. However, at the temperature of 35 °C and higher, close to the phase transition, a significant deviation from its Newtonian behavior is observed due to precipitation of polyvinyl methyl ether as it forms a solid white mass. Through the use of the Arrhenius–Frenkel–Eyring equation, the activation energy of the viscous flow for polyvinyl methyl ether solutions was found to be 31 kJ/mol. Based on refractometry data, it was demonstrated that phase transition in aqueous solutions of polyvinyl methyl ether is reversible. This feature can facilitate medical equipment cleaning before introducing the embolic agent into a patient’s bloodstream. Finally, the investigation determined some parameters, in which the formation of embolic agents from a 30% polyvinyl methyl ether aqueous solution occurs (in situ in a blood vessel at a temperature of 35.5 °C).

Keywords

• embolization
• embolic agent
• viscosity
• polyvinyl methyl ether
• aqueous solution