Exosome-hydrogels loaded with metal-organic framework improve skin aging by inhibiting oxidative stress

Abstract

Solvothermal reactions of Ba(NO3)2 with 1,3,5-benzenetricarboxylic acid gave rise to a new coordination polymer of [Ba6(BTC)4(H2O)9]}n (1 H3BTC = benzenetricarboxylic acid). The complex 1 was characterized soundly by Fourier transform infrared (FT-IR) spectroscopy, elemental analysis (EA), single-crystal X-ray diffraction (SCXRD), and thermogravimetric analysis (TGA). The framework of 1 has high thermal stability and shows intense luminescence at room temperature. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) have good biocompatibility, based on the chemical synthesis method, the HA/CMCS hydrogel was prepared. With exosomes as drug models, we further synthesized novel exosome-loaded metal gel particles and evaluated their effects on oxidative stress in human dermal fibroblasts.

Keywords

• ba(ii) compound
• luminescence
• hydrogels
• exosome
• skin aging